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Elle peut se
déclarer à tout âge, néanmoins les plus touchées sont les chiennes de plus de
sept ans. Généralement, la période à risque se situe entre six et huit semaines
après la fin des chaleurs pendant la période dite du metoestrus. En effet, à ce
moment le taux de progestérone est élevé. Or cette hormone stimule la
prolifération des glandes de l’utérus et leur sécrétion. Ceci crée un milieu
favorable à une infection. Le pyomètre résulte donc d’un dérèglement hormonal.
Il est donc favorisé par l’utilisation de progestatifs (substances qu’on utilise
pour prévenir les chaleurs). L’interruption des chaleurs et l’avortement sont
également mis en cause. Il est donc fortement déconseillé de vouloir stopper les
chaleurs de votre chienne, vous lui feriez courir un risque important.